x,3,1 DuMez: Emetine in Treatment of Entameebiasis 79 
slowly at the very seat of the trouble. The comparatively poor 
results obtained from the administration of emetine by mouth 
is very probably due to its too rapid absorption and elimination, 
as has already been pointed out. 
These two compounds can be given in doses representing 0.03 
gram of emetine hydroiodide without causing vomiting and 
without any apparent nausea; but vomiting does occur when 
either of them is given in very large doses, as is shown in the 
following tabulation of experiments conducted with dogs: 
TABLE 1V.—The effects of emetine mercuric iodide and of emetine 
bismuthous iodide upon dogs. 

ia Substance. Notane! Dose. | Time given. Vomiting. 

\ | Kilos. Gram. 
Emetine mercuric iodide __-__ _________- 8.7 0.057 | 10.25 a. 


m. | None at 2 p. m. 
PER Cy BRS Sse POT: WOU ge a eA AT | 8.8 0.092 | 10.83 a.m. | At 11.26 a. m. 
Emetine bismuthous iodide____-_________ | 7.8 | 0.066 | 10.38 a.m. | None at 2 p.m. 
eRe ese cae UM a acd | 6.3| 0.075 | 3.22p.m. | None at 5.30 p. m. 
m. | At 11.50 a. m. 




TDs Sis ones ie ve Ys cane Satie oe aN tS | 9.8 0.012 | 10.40 a. 

In these two compounds, then, we may possibly find a remedy 
which can be administered frequently, in fairly large doses, and 
with a minimum amount of trouble, and which will bring eme- 
tine in contact with the entamoebe for a comparatively longer 
time than is true with the forms in which it is administered 
at present. i 
