102 The Philippine Journal of Science 1915 
changed, and the allantoin was increased to five doses daily. 
No further improvement was noticeable, and the patient was 
discharged at the end of twenty-five days. The albumin in the 
urine had gradually diminished to a trace. The patient seemed 
practically normal as to the condition of the mouth, the gait, 
_and general comfort, and the cedema had disappeared. 
CASE 3 
A woman, aged 26 years, was admitted to the hospital with 
a sick child 2 months old that she was nursing. She dated 
her illness from about the sixth month of pregnancy and suf- 
fered from that time with swollen legs, pains in the calves, 
and a feeling of weakness. The child was her first. Three days 
after the birth of the child she felt numbness of the legs and 
formication, which still continued at the time of her admission 
to the hospital. She looked weak and anzemic and complained 
of headache, sleeplessness, sense of heat in the chest, pain in 
the back, and inability to walk with comfort. The calves of 
the legs were tender, and the refiexes very slightly sluggish. 
‘G@dema of the legs was slight. 
The area of heart dullness was very little increased. An 
indistinct systolic murmur was heard only at the apex, and 
the second sound was strongly accentuated. Respirations were 
rapid, deep, and full. A dry musical rale was audible over the 
apex of the right lung. The patient had suffered from a cough 
for some months, which appeared to be largely laryngeal. The 
urine showed no abnormal character. 
The patient was given. 0.4 gram of allantoin three times 
daily. She showed no marked improvement in any respect 
during several days. Later the distress in the chest became 
more severe, and the heart murmur was more distinct. The 
allantoin in larger doses seemed to have a depressing effect. It 
was, therefore, stopped, and digitalin was administered with the 
usual effects. She was discharged after twenty days without 
having been materially benefited by the treatment. 
CASE 4 
A woman, aged 25 years, mother of 2 children, the youngest 
being a nursing infant of 3 months, was admitted to the hos- 
pital. She complained of having felt numbness in the limbs 
for two months with formication at times. She was pale and 
anemic, had little appetite, and felt dizziness and painful op- 
pression in the chest. There was some cedema in the legs, no 
