x, B, 2 Williams and Saleeby: Treatment of Human Beribert 109 
She was given 15 cubic centimeters of hydrolyzed extract 
three times daily for two weeks. She soon felt and looked much 
better. The pains disappeared first, and the numbness de- 
creased in area until only the toes remained anesthetic. The 
patient could walk much more steadily and comfortably. The 
heart condition and the patellar reflexes remained unchanged. 
The patient nursed her infant throughout the treatment. 
CASE 15 
A woman, aged 30 years, was admitted to the hospital with 
an infant that showed some evidence of beriberi. The mother 
complained of numbness of all the extremities and of the body 
up to the shoulder and of pain in chest and between the shoulder 
blades. The illness dated from the birth of the child three 
months previously, although numbness of the legs was expe- 
rienced after the birth of each of 8 previous children. Of 9 
children she had borne, 5 died before reaching an age of 3 months. 
In each case death was sudden, but the cause was unknown. 
When first seen the mother felt weak and dizzy. Formication 
and dyspnoea were marked. The area of heart dullness was in- 
creased to right and left. The first sound was short and pre- 
sented a slight murmur; the second was accentuated and some- 
what dull. The knee jerks were diminished. No cedema was 
apparent. The urine showed no albumin nor casts. 
Twenty cubic centimeters of hydrolyzed extract were given 
three times daily; later the dose was increased to 30 cubic centi- 
meters. The patient felt much more comfortable after treatment 
for several days, and all the symptoms diminished in severity. 
She continued to nurse her child during treatment. 
CASE 16 
An infant of 5 months was admitted with the mother (case 
15), who said the child was well. It appeared well nourished, 
but showed a general cedema over body and face. Its movements 
were sluggish and rather weak. It was not treated directly, but 
the mother, who continued to nurse it, was given from 20 to 30 
cubic centimeters of hydrolyzed extract three times daily. The 
child soon became noticeably brighter, stronger, and more active 
and gained rapidly in weight. 
CASE 17 
An infant of 2 months was admitted with the mother, who was 
evidently beriberic. The child had been sick four days, had ap- 
parently had colic, and had been cyanotic in the face. The 
parents had lost their first and only other child by a similar 
