x, B, 2 Williams and Saleeby: Treatment of Human Beribert 11 
diagnosed as beriberi and treated with extract of rice polishings 
by Doctor Castafieda. When seen by us, the child was somewhat 
cedematous all over the body, the voice was hoarse and aphonic, 
and the area of heart dullness was increased slightly. It was 
very restless and peevish. 
After treatment with extract of tiqui- tiqui in quantities from 
4 to 24 cubic centimeters daily for a week, the child gradually 
improved in every respect and seemed quite well, except for a 
slight huskiness of the voice. 
CASE 19 
An infant of 2.5 months was admitted on October 5 with its 
beriberic mother (case 4). The child had been coughing for a- 
few weeks. The throat was a little sore, and the voice was very 
aphonic. The child was pale. There was general cedema, es- 
pecially in the legs. The urine was somewhat scanty; the ap- 
petite was good, although vomiting after meals was frequent. 
The heart seemed slightly enlarged downward, but otherwise 
normal. The patellar reflexes were rather exaggerated. 
On October 8 treatment was begun with 1 cubic centimeter 
of tiqui-tiqui extract four times daily. Improvement was rather 
slight for about a week, although the vomiting was much di- 
minished. Later a general improvement in the appearance and 
temper of the child was apparent. The cedema disappeared, the 
vomiting ceased, and the child became strong, active, and 
vivacious and gained 11 ounces in weight during the third week. 
The voice improved very markedly. The child continued to nurse 
the beriberic mother, who first received allantoin without im- 
provement, and later received hydrolyzed extract with somewhat 
better results. The later improvement in the child was no doubt 
in part due to the hydrolyzed extract received by the mother. 
CASE 20 
An infant of 6 weeks was admitted to the hospital with the 
mother, who was beriberic (case 14). The infant had had an 
acute attack of infantile beriberi a week previous to admission. 
It had been cedematous all over the body, and at times, according 
to the mother, its limbs had become rigid. Having been treated 
by Doctor Castaneda with extract of rice polishings before en- 
tering the hospital, it was much improved. Only a slight puffi- 
ness of the face and a general weakness of movement remained. 
It was further treated with extract and rapidly gained in 
strength, weight, and general appearance. 
