114 The Philippine Journal of Science 1915 
a hypodermic injection of 80 milligrams of crude semicrystallized 
vitamine, to which some brown sirupy mother liquor still adhered. 
The temperature rose rapidly within a few hours and reached 
40°.3 during the night. After thirty-six hours the temperature 
had again become normal and has since remained so. Some 
redness and induration appeared at the point of injection, which 
has since practically disappeared. Forty-eight hours after the 
injection the baby was bright and active and seemed quite well. 
In spite of the period of high fever the child gained 5 ounces in 
weight in three days after the injection. The gain continued 
and amounted to 15 ounces at the end of one week. 
CASE 24 
A baby, 2 months old, was admitted on November 3; it had been 
sick two weeks. It was pale, cried frequently, and appeared to 
have pain in the stomach; it had vomited often for several 
days. There was slight dyspnea, and the movements of the child 
were slow and weak. The heart beats were rather forceful and 
equally spaced. The mother was beriberic. 
At 4 o’clock in the afternoon of November 3 the child was given 
the semicrystallized vitamine obtained from 10 kilograms of 
rice polishings. It vomited copiously immediately, and a little 
later the dose was repeated. The temperature rose after a few 
hours, reaching nearly 39°, and then subsided gradually. The 
next day the child’s condition had changed radically. It had 
not vomited since taking the vitamine and appeared well, 
bright, and contented. It gained 29 ounces in weight during a 
week, although it had appeared well nourished from the first. 
CASE 25 
A well-built athletic man, aged 20 years, was admitted to the 
hospital after a month’s illness, previous to which his personal 
history appeared negative. His illness began with heaviness and 
numbness of the legs. Later, formication, tenderness of the 
muscles, general cedema, paresthesia, and weakness appeared. 
When first seen, the heart showed a readily visible diffuse impulse 
in the fourth and fifth interspaces. The area of heart dullness 
was increased upward and downward, a little to the left but 
most markedly to the right. A faint diffuse systolic murmur 
and accentuation of the second sound were audible. There was 
marked visible pulsation in the veins of the neck, and the pulse 
was of the water-hammer type and easily compressible. The 
lungs were negative. The calves were markedly tender, and the 
