Sgr, 2 Barber: Experiments on Immunization 159 
TABLE X.—Series A. Animals inoculated with material from enlarged 



















spleens. 
~ ape) aT Peery go) OR 
2g Weight. 5 Autopsy. 
3 | | Ye | 
ae — ° —— ae 
S go | | = EO. 
iS hake 5 oN se : + 
a & 2 | Date of inoc- hl gq act a6 = 2 ob 
3} 2 ulation. ss a Sp Po 3 2 Ds g 
ie leRemes i i - : oa 
g 2 |2¢ 1a leis. 5 a ga | Om 
& i |) BS | pS $ fl te. > % S|] dg Or3) 
3 o ] ad 8 ® a |S 8 S Rll Ales 
SQ ii le 2) 2 | = 12 ca |) a i ell] | 
. aaa ial | 
g- 1912 g 9g. g. |Days.) 9g g 
5221 | 680 | 6221 | Aug. 16.____- EXO) eee eee 98 | 410 | 18.2 | Tb. | 0.0328 
5216 | 460 | 6221 |___-_ doje: 2 AZO) Reese Sus eo 96 | 410 | 12.5 | Tb. | 0.0305 
6400 | 500 | 6218 | Sept. 7_.----- 470 | 480. |__--__ IGE} |) Sisto) ee D3 i|saee5 5225 
6401 | 670 | 6218 |__-_- does BO) I} BY) fees 20M 510) 250) | abs 9050089 
6426 | 410 | 6220 | Oct. 4 ---__-- 430 | 480] 420 201} 360] 5.6] Tb. | 0.0156 | 
6427 | 450 | 6220 |.___- doen 330 | 350} 370} 222] 320) 1.6} Tb. | 0.0050 
6428 | 450 | 6220 |____- dols-n22 460 | 490 | 490 | 224) 400] 5.0 Tb. | 0.0125 
iene (eae Bae eecetoe | e peseetiseeaaci 
IACVeT a eles Re eee ies (Ai | Eraser ol 656) Eee 0. 0167 


A striking result in the autopsy findings in series A is the 
unusual enlargement of the spleen. This was shown in both 
culture-inoculated and spleen-inoculated groups. The weight of 
the spleen at autopsy showed the very high maximum of 14.7 
grams to 410 grams body weight in animal 6221, and the high 
average of 6.9 grams for all of series A of which spleen weights 
were taken. 
As a basis of comparison the ratio of the spleen weight to the 
body weight at autopsy was calculated for a considerable number 
of the guinea pigs dying of tuberculosis of human-sputum origin. 
These animals belong to series 1, 2, and 3, treated animals of 
part I of this paper, and the controls of that series. The aver- 
ages of these ratios compared with those of leper series B are 
given in Table XI. 
TABLE XI.—Average ratios of spleen weights to body weights in all series. 





=e 
Aver- | Aver- 
ageof age : 
Table ratios,| sur- ao, 
| Series. N Origin of tubercle bacilli inoculated. | spleen | vival 
oO. . aver- 
weight| after Aral 
to body| inocu- | *2°°- 
weight.| lation. 
Days. 
1 Yee aS 5 cen ee a oe ey I Sputum ee aera cee eer Lae | 0.0069 | 286.6 9 
i re I a! MU iL 9 [ae (0 (0 eee ee a ene ee eS EN 0.0084 | 308.8 25 
Bee eae eh ah eS ee WOH freee SVS ee main Sek aks EY ea ya 0.0072 | 310.7 11 
Wontrolseee see ee eee Tees eae (6 (Gy See tein Re 0.0088 | 340.6 10 
SNe Rh hE eB 8 BS 3 ae Vv Leperispleen? ees i Ss LL eS 0.0191 | 134.6 12 
JN aoe eee tee aS ee WA (or) oe cee (Clete ee ns se ee ek eee 0.0167 | 173.7 6 









