38304 The Philippine Journal of Science 1915 
orrhages also occur in all parts of the kidney, beneath the 
capsule, beneath the pelvic mucosa, and in the cortex and pyra- 
mids. Cidema may widely separate the tubules, and it is not 
infrequent to find fine threads of fibrin in the intertubular vessels. 
This fibrin is attached to the walls of the vessels, and the endo- 
thelium to which it is attached may show no change; in other 
cases the endothelial cells are decidedly enlarged. 
Glomerular changes may also be marked, and these form the 
most characteristic change in the kidneys in plague. However, 
marked glomerular changes are not present in all cases, as in 
some the changes in the tubular epithelium, as above described, 
may be predominant. Degeneration and vacuolation of the 
epithelium covering the tufts may be present. As a rule the 
changes in the epithelium lining Bowman’s capsule are slight. 
The capsular space frequently contains a granular retic- 
ulated material, similar to that found in the tubules. Occasion- 
ally red blood cells are also found here as well as desquamated 
epithelial cells. Much more rarely are leucocytes found in the 
capsular space. Congestion of the tuft capillaries is very fre- 
quent. In 41 per cent of my cases fibrin thrombi were found 
in the tuft capillaries. This fibrin may be in the form of fine 
threads, which are adherent to the walls of some of the tuft _ 
capillaries, or may completely fill some or all of the capillaries 
of some or all of the tufts in a section. The larger thrombi 
can be readily recognized with the hemotoxylin and eosin stain, 
but the smaller threads may require a selective stain, such as 
Weigert’s fibrin stain, for their detection. The endothelium 
lining the capillaries does not show evidence of marked change 
in those cases with thrombosis. 
The bacilli occur in relatively small numbers in the kidney 
as compared with the bubo or spleen. They may be found in 
the vessels of the kidney, as in all parts of the body. They 
are, at least, not always demonstrable in association with the 
vascular thrombi. 
GENERATIVE ORGANS 
These organs are not frequently the seat of marked change. 
Hzemorrhages have been encountered in the mucosa of the uterus, 
in the peritoneum covering it, in the ovaries, in the testes and 
epididymes, and along the course of the vas deferens. 
In the uterus of one of our cases was a 6-month fcetus, and 
another uterus was enlarged, with adherent placenta and dilated 
cervix, the patient having aborted a fetus of about the eighth 
month the day before death. 
