X, B, 6 Denney: Skin Lesions of Leprosy 359 
Accordingly, without regard to the character of the lesions, 
132 patients were selected from the members of the colony for 
experimental treatment. 
Since a majority of the ulcers are continuously bathed 
in serum, it was at the outset considered inadvisable to use 
ointments, experience having shown this form of medication to 
be unsatisfactory. Cotton pledgets, soaked in 1 to 500 aqueous 
solution of basic fuchsin, were packed into the lesions and kept 
in place by gauze bandages. After a few days the patients com- 
plained of a burning sensation in the lesions, and thereafter a 
solution of 1 to 1,000 was adopted for routine use with little or 
no discomfort. 
The lesions treated may be classified as follows: 
. Ulcerated tubercles. 
. Neurotrophic ulcers: 
. Infected neurotrophic ulcers. 
Simple burns. 
. Infected burns. 
Ulcers with sinuses leading to necrotic bone. 
. Early gangrene (superficial). 
. Late gangrene (deep). 
Te pyesasce 
a. Ulcerated tubercles (Plate I, fig. 1) responded rather slowly 
to basic fuchsin treatment. Within a few weeks, however, the 
lesion assumes a pink, healthy appearance, which may con- 
tinue until the epithelium finally covers the wounds, leaving 
raised, flat, smooth cicatrices. Of the four cases treated, one 
eventually repaired, one showed considerable improvement, 
and two were unimproved after five months of treatment. 
b. Neurotrophic ulcers (Plate III, figs. 1, 2, and 3), many of 
which had resisted treatment for long periods of time, quickly 
showed improvement. The epithelial margins approximated, 
leaving smooth, pink cicatrices. The repair, however, not being 
permanent, subsequent trauma resulted in new ulcers. Thirty- 
three cases were treated, fifteen of which continued to complete 
repair, fourteen improved considerably, three did not improve, 
and one died (from leprous cachexia). 
c. Infected neurotrophic ulcers (Plate II, figs. 4 and 5) 
responded to treatment in a manner similar to simple neuro- 
trophic ulcers, the infection being checked readily and repair 
continuing. Of the six cases treated, four continued to complete 
repair, while one died of meningitis and one from septicemia 
(each of these two patients was extremely ill when treatment 
was started). 
d-e. Simple and infected burns are very frequent lesions in 
