BOON gs The Philippine Journal of Science 1915 
TABLE I.—Showing condition of the gall bladder and biliary passages. 
Signs of inflam- 
Gholera mation. 
Year. autop- |————_—_———___| Stones. 
Gall Bile 
bladder. | ducts. 






a Thirty-nine of the gall bladders in the 1913-14 series at the time of autopsy were tied off 
at the common duct and sent to the Bureau of Science, Manila, where they were examined by 
Dr. Otto Schébl. He records his results in a recent paper. The cholera vibrio was found in 
17 of the cases on bacteriological examination of the bile. Three cases showed macroscopic 
pathological changes in the gall bladder, and in two hydrops cystis fellee was found—that is, 
distended gall bladder containing mucus, bile of light amber color, and flaky sediment. One 
showed thickening of the wall with distended blood vessels, desquamation, of the mucosa, and 
round-cell infiltration. 
Table I shows that in the last two years—1913-14— there were 
13 cases in 305 that showed signs of inflammation of the gall 
bladder, or about 4 per cent. In order to demonstrate if there 
were microscopic pathological changes in cases with no macros- 
copic lesions of the biliary passages, and to demonstrate the 
exact location and condition of any cases with gross or minute 
pathological changes, the following method was adopted. For 
histological examination five sections of the gall bladder and 
bile ducts were taken as follows: 
1. Common duct. 
2. Hepatic duct near the hilus. 
38. Hepatic duct and liver tissue halfway between hilus and border of 
liver. 
4. At border of liver. 
5. Wall of gall bladder. 
These sections were fixed in Zenker’s solution in separate 
bottles, imbedded in paraffin in the usual manner, and cut and 
stained with hematoxylin and eosin. Twenty-eight unselected 
cases were examined in this manner. One of these cases (No. 
3609) showed some gross pathological changes: namely, the gall 
bladder was dark gray and filled with thick, black bile and the 
blood vessels were injected. On microscopic examination the 
epithelial layer of the mucosa was found to be desquamated and 
the blood vessels of the submucosa were distended. There was 

