﻿96 The Philippine Journal of Science 1914 



Immediately following, that is within twenty-four hours of, the intrave- 

 nous injection of salvarsan we have seen the stools change from a mixture 

 of pus and blood to those having a greenish bile color. 



In every case but one the number of stools per day has been reduced 

 from one-third to three-fourths in twenty-four hours. 



Arsenic has been demonstrated in the stools and urine as early as five 

 hours after administration and for as long as eighteen days. 



In all cases except one we have seen the amoebae disappear from the 

 stools in from twenty-four to seventy-two hours. 



Winn's work was carefully performed, numerous laboratory 

 examinations for entamcebae evidently being made, but the 

 exact dates are not given. The report of the subsequent his- 

 tories of these patients, which is promised, will be exceedingly 

 interesting. 



Milian(28) reports the rapid recovery of a case of amoebic 

 dysentery in response to salvarsan. 



Wadhams and Hill (29) report 3 cases of entamcebic dysen- 

 tery treated with salvarsan with successful results. Their cases 

 are, however, more or less indefinite. All of the patients were 

 American soldiers who had contracted entamcebic dysentery in 

 the Philippine Islands several years previously. The disease had 

 apparently become chronic in each case. The report indicates 

 that the authors never saw entamcebae in the stools of two of the 

 cases either before or after treatment and that in one of these the 

 examination was made about one year after the administration 

 of salvarsan. Entamcebae were present before and absent after 

 treatment in the remaining case, but the number of stools ex- 

 amined after treatment is not mentioned. 



The results obtained in our 8 nondysenteric cases treated with 

 neosalvarsan are given in Tables V and VIII. We believe that 

 these results and those of Winn are too remarkable to be ex- 

 plained by mere coincidence. We are, therefore, inclined to be- 

 lieve that this treatment will prove to be the most efficacious of 

 the four under discussion in actually curing dysenteric and non- 

 dysenteric entamoebiasis. If so, a drawback to its common use 

 would be the cost of this therapeutic agent. 



The bismuth, or better the bismuth-milk-saline, treatment of 

 entamcebic dysentery caused by E. histolytica is advocated by 

 Deeks(30) of the Ancon hospital, Ancon, C. Z. This author 

 states that in 60 consecutive cases he has not had a single death 

 unless some complication were present and that in 190 cases 

 treated by this method there has been not one relapse. It is 

 also stated that in only two of all the cases treated by this 

 method were entamcebae of the species E. histolytica found in the 



