﻿230 The Philippine Journal of Science 1914 



guinea pig were all negative at the end of two months. This 

 animal died some nine months later, and the liver, lungs, spleen, 

 and some of the lymphatic glands showed marked nodular in- 

 volvement. Smears from the different organs showed a few 

 acid-fast bacilli. Sections were examined by Dr. B. C. Crowell 

 of the Bureau of Science, who reported that the lesions would, 

 ordinarily, be described as tubercular. Cultures made from the 

 spleen on placental agar showed after two weeks a growth prac- 

 tically identical with the first isolation. Efforts to identify the 

 organisms isolated by means of agglutination and deviation of 

 complement tests have been so far unsatisfactory. 



So far as I know, but two other investigators have injected 

 a streptothrix and recovered an acid-fast rod ; these were Bayon 

 of London and Kedrowski of Moscow. Bayon also recovered a 

 streptothrix after inoculating a rat with this acid-fast rod. At 

 the present time I have a series of animals under observation to 

 test whether or not the acid-fast rod becomes a streptothrix in 

 the animal body. I have noted, however, a decided tendency 

 for the cultures of the acid-fast rod form to throw back, as it 

 were, and show decided streptothrix forms. In conclusion I 

 can only say that at this stage of my work I am quite convinced 

 that Bacillus leprae is but the acid-fast stage of a markedly pleo- 

 morphic streptothrix. 



BIBLIOGRAPHY 



1. Hansen, A. Norsk. Mag. f. Laegevidensk (1872), 2, 1. 



2. WoLBACH, S. B., and Honeij, James A. Journ. Med. Research (1914), 



29, 367. 



3. Jordan, E. 0. A textbook of General Bacteriology. W. B. Saunders 



Company, Philadelphia and London. 3d ed. (1913), 347. 



4. FouLERTON, A. G. R. Lancet (1910), 1, 551, 626, 769. 



