﻿278 The Philippine Journal of Science i9i4 



The next and most spectacular stage of congestion was noted 

 in the lower portions of the lobes. The portal veins were 

 usually distended with blood, the interlobular capillaries around 

 the edges of the lobules were markedly congested, while in 

 the central portion of the lobules around the hepatic vein (Plate 

 II, fig. 1, a) the congestion reached such a degree as to cause 

 rupture of the capillaries. These markedly congested and 

 hsemorrhagic portions varied from one-fourth to three-fourths 

 of the area of the involved lobules. The parenchymatous tissue 

 in these regions had practically disappeared. Now and then 

 a liver cell was present which had not as yet undergone necrosis. 

 The parenchymatous tissue around these areas was found in 

 all degrees of degeneration, being mildest near the capsule of 

 the lobules. An abnormal number of round cells and eosino- 

 philes were found in the capsular tissue, also penetrating into 

 the parenchjonatous tissue, and surrounding the individual liver 

 cells. In a few instances, bile ducts were noticed undergoing 

 proliferation in this area. 



The next stage noticed was that in which the lobules had 

 become necrotic and were filled with blood from haemorrhages. 

 These areas were most frequently met with at the extreme 

 dependent portions of the lobes (Plate I, fig. 1, a). The 

 hsemorrhagic areas contained large numbers of round cells and 

 eosinophiles. The capsule was congested and infiltrated with 

 leucocytes. The connective tissue of the capsule showed signs 

 of degeneration, especially infiltration with a granular, fibrinous 

 exudate. 



In those areas of the liver which the worms had invaded, 

 marked pathological changes were encountered. Sections of 

 worms were frequently found. Surrounding the worm was an 

 accumulation of leucocytes and cell detritus, external to which 

 was a fibrous connective tissue wall. More frequently the track 

 of the worm was found, which was represented by a round or 

 oblong mass of cell detritus mixed with round cells and fibrin, 

 and surrounding this mass of material was the fibrous connective 

 tissue wall. 



In the immediate vicinity of these invaded areas, there was 

 marked development of connective tissue. In many instances, 

 the interlobular connective tissue had developed to such an extent 

 as to crowd the lobules out of existence. In some instances, 

 lobules were found varying from three-fourths to one-fifth of their 

 normal size. The liver cells were atrophied, from the pressure 

 brought on them by new-forming connective tissue. The most 



