﻿428 



The Philippine Journal of Science 



1914 



cases mentioned in the footnote, and consequently the patients 

 are known to have received the doses stated in the table. 



Table VIII. — Effect of quinine treatment on infection of anophelines with 



malarial parasites. 



No. of 

 pa- 

 tient. 



Days used 

 for exper- 

 iments. 



Quinine 

 by mouth 

 during ex- 

 periments. 



Quinine 

 intrave- 

 nously dur- 

 ing exper- 

 iments. 



Average 

 quinine 

 per day 

 during ex- 

 periments. 



Mosquitoes 

 dissected 

 that fed 



on patient. 



Mosquitoes 

 infected. 



Average 

 oocysts to 

 an infected 

 mosquito. 







Grams. 



Grains. 



Grams. 





Number. 



Per cent. 





808 



17 



5.83 



9.0 



0.85 



60 















1251 



6 



0.64 



7.2 



1.3 



3 















1372 

 1413 



8 

 3 





 0.97 



0.9 

 0.9 



0.3 

 0.62 









1 





 4.54 





 1.0 



22 



1261 



13 



5.18 



9.0 



1.09 



82 



5 



6.09 



37.0 



1486 



3 















12 















1506 



2 















12 



1 



8.3 



3.0 



1345 



2 















21 



2 



9.5 



3.0 



223 



22 



6.80 



10.8 



0.8 



271 



21 



7.7 



11.5 



1240 



3 



2.59 







0.86 



15 



1 



6.6 



1.0 



1548 



3 



(•) 



1.8 



0.6? 



19 



2 



10.5 



2.5 



1612 



16 



0.97 







0.06 



256 



46 



17.9 



b3.09 



1197 



6 



9.7 







1.62 



96 















1659 



6 



1.29 



0.9 



0.44 



57 















1312 



5 



C4.86 







0.97 



252 



74 



29.3 



b5.7 



1786 



2 















44 



10 



22.7 



20.0 



1806 



7 



9.07 







1.29 



83 



34. 



40.9 



28.8 



" Given quinine to take at home. 



•> Several of the infected mosquitoes had only sporozoites in their salivary glands ; therefore, 

 they bad at least 1 oocyst in the mid-gut and possibly more. 



' Given quinine to take at home. The patient said that he took the amount stated. 



From these data it does not appear that the quantity of quinine 

 taken by the patient during the time he was used for infection 

 experiments had any influence upon the percentage or intensity 

 of infections of the mosquitoes, 



NUMBER OF EXPERIMENTS 



Anopheline mosquitoes, bred from larvae, distributed among 

 227 cages were fed on malaria patients whose blood contained 

 gametes of the malarial parasite. Some of these cages were 

 combined, after the mosquitoes had fed, to form the 184 experi- 

 ments recorded in Table I. In our earlier experiments our 

 technique was not fully developed, difficulties in keeping the 

 mosquitoes alive were encountered, and the results were not 

 quantitative; later our technique was improved, the difficulties 

 were overcome, and the experiments were made to yield quanti- 

 tative results. It has, however, been considered advisable to in- 

 clude all of our experiments, the failures as well as the successes, 



