﻿452 The Philippine Journal of Science 



fections apparently contracted in Manila probably occurred 

 elsewhere. 



4. The majority of the infections occurred among adult male 

 Filipinos. 



5. Malarial organisms were found in 85.1 per cent of 341 cases 

 examined microscopically. Failure to find them in a higher per- 

 centage was probably due to (a) rendering a positive clinical 

 diagnosis upon scanty laboratory work; (6) absence of organ- 

 isms from the peripheral circulation; (c) errors in the labor- 

 atory; and {d) errors in the clinical diagnosis. 



6. Malarial lesions were found in 5.6 per cent of autopsies per- 

 formed upon individuals who died at the Philippine General 

 Hospital. A correct clinical diagnosis was rendered in 73.7 per 

 cent of the cases. Organisms were found microscopically ante 

 mortem in 13, or 86.7 per cent, of 15 cases examined. In the 2 

 cases which were negative, chronic lesions were present and 

 death was not due to malaria. 



7. In miscellaneous laboratory work upon 185 cases which wei'e 

 admitted to the hospital because of malaria, and which were pos- 

 itive both clinically and microscopically, special attention was 

 given to the leucocyte counts. In 131 of the cases a leucopenia 

 was present in 47.3 per cent; a normal count, in 42.7 per cent; 

 and a leucocytosis, in 10.0 per cent. Some of the normal and 

 abnormally high counts may be explained by the supposition that 

 the blood was taken during sporulation in light or chronic cases 

 and between paroxysms in heavy acute cases. It is believed, but 

 not proved, that intestinal parasitism and disorders of the genito- 

 urinary tract are responsible for some, at least, of the normal and 

 abnormally high counts. 



8. Typhoid fever being excluded, the malarial splenic index 

 was 69.5 among the first 1,000 thoroughly examined medical cases 

 admitted to the hospital during the year. Malaria was not sat- 

 isfactorily excluded from a number of the cases with enlarged 

 spleens. Typhoid fever likewise being excluded, malarial or- 

 ganisms were found in 85.7 per cent of 264 cases with enlarged 

 spleens examined microscopically. Organisms could have been 

 found in a number of the negative cases had treatment been 

 delayed. 



