﻿504 The Philippine Journal of Science wu 



Rashes sometimes occur after the ingestion of strawberries, 

 and a lymphagogic effect for these has been demonstrated by 

 Clopatt ^ and by Mendel and Hooker.* Our work has shown con- 

 clusively that the mango is also to be included with Heidenhain's 

 lymphagogues of the first class. 



Dogs, anesthetized with ether only, were used in the 14 ex- 

 periments performed. Extracts of the dried mango pulp (3 

 experiments) were less effective than the strained and centrifu- 

 galized raw juice which we employed in the remainder of the 

 series. Mendel and Hooker arrived at a similar conclusion with 

 strawberry extracts. Lymph was collected from the thoracic 

 duct. The dogs had not been fed since the day preceding. In- 

 jections of the mango juice, at 30° C, were made from a burette 

 into the saphenous vein. Determinations of the total solids of 

 the lymph, collected over ten-minute periods, were made in 6 

 experiments. The samples were dried on the water bath and 

 then heated in the oven at 105° C. until the weight was constant. 

 Blood pressures were recorded graphically with a mercury mano- 

 meter in the usual way. Blood samples (about 5 cubic centi- 

 meters) were collected in test tubes from the femoral artery, a 

 clean, dry, glass cannula being employed each time. Sufficient 

 blood to wash out the cannula was allowed to pass through before 

 the sample (in duplicate) was taken. The blood was considered 

 to have clotted when the tubes could be reversed without spilling. 



The results of two of the experiments in which the total solids 

 of the lymph were determined are given in Tables I and H. 

 These experiments show an increased flow of lymph of almost 

 three times the normal. This lymph is richer in solids than the 

 samples collected before the injection. Blood pressure under- 

 went the typical fall to be expected from lymphagogic substances. 

 The clotting time of the blood is slightly extended in experiment 

 10 (Table I), but is shortened in experiment 11 (Table II). We 

 have observed this unexpected result in several of our experi- 

 ments. Every sample of lymph which we collected promptly 

 clotted.* 



That the mango juice may produce the typical inhibition of 



'Skandin. Arch. f. Physiol. (1900), 10, 403. 



•Am. Journ. Physiol. (1902), 7, 380. 



* Experiments have been reported in dogs with thoracic fistula in which 

 the clotting time of the blood was only slightly, if at all, affected by proteose 

 injections, while the coagulability of the lymph was delayed. Spiro and 

 Ellinger, Zeitschr. f. physiol. Chem. (1897), 23, 135; Chittenden, Mendel, 

 and Henderson, Am. Journ. Physiol. (1889), 2, 142. 



