﻿IX, B, 6 Gibson & Concepcion: Lymphagogic Action of Mango 505 



blood clotting is shown in the following experiment in which no 

 thoracic fistula was made : 



Experiment 11, June 25, 19H. — Male dog, weighing 5.8 kilo- 

 grams. Normal blood obtained at 9.40 a. m. clots in fifteen 

 minutes. At 9.45 a. m. the dog received a rapid injection of 40 

 cubic centimeters of fresh mango juice. Blood pressure fell 

 immediately from 178 to 45 millimeters. Blood samples ob- 

 tained five, ten, and thirty minutes after injection failed to clot 

 in twenty-four hours. 



That a certain degree of tolerance or immunity r'esults from 

 consecutive injections, both for lymph flow and blood pressure, 

 is shown in experiment 12 (Table III). In this experiment only 

 from 17 to 20 cubic centimeters of the juice were given at a 

 single injection, as the dogs do not withstand very well the 

 repeated administration of larger amounts. In the latter case, 

 the second injection may be nearly as efficient as the first, as 

 shown in experiment 8 (Table IV) . 



Clopatt has shown that the quantities of sugar and salts, 

 in the berry extracts employed, were too small to ascribe the 

 marked results obtained to a lymphagogic effect of the second 

 class (Heidenhain). Mendel and Hooker calculated that the 

 maximum amount of sugar used in the largest injection of straw- 

 berry extract would not exceed 0.2 gram per kilogram of 

 body weight of the dog used. The mango pulp has the following 

 composition : 



Com/position of mango pulp.'' 



Per cent. 



Water 82.8 



Solids 17.2 



Sugar (as invert sugar) 13.24 



Acid (as citric acid) 0.18 



Protein 0.22 



Crude fiber 2.6 



Ash 0.45 



The sugar given in experiment 10 (Table I) amounts then 

 to only about 0.3 gram per kilogram of body weight. Further- 

 more, the increase in total solids of the lymph collected after 

 the injection of the mango juice is characteristic of the first 

 and not of the second class, or crystalline, lymphagogues. With 

 the second class, in fact, there is usually a diminution of the 

 total solids. The additional evidence of the constant fall in 

 blood pressure, the observation that the mango juice may produce 



'Pratt and del Rosario, This Journal, Sec. A (1913), 8, 59. 



