320 R. M. Chittenden — Papoid-digestion. 



ment. This, as seen from the result, did not materially interfere 

 with the digestive action of the ferment. 



Strychnin and Brucin Sulphates. 



The 10 grams of prepared raw beef contained 2 •707 grams of dry 

 proteid (dried at 110° C). 



The mixtures Avere warmed at 45° C. for 6^ hours. 



Alkaloid salt. Weight of undigested residue. Proteid digested. 



0-7175 gram 73*4 per cent. 



0-25 per cent. Strych. sulph. 1-2006 " 55-6 



0-50 " " 0-9089 " 66-4 



0-25 " Brucin sulph. 8461 " 687 



0-50 " '* 0-8068 '' 70-1 



These results show that the two alkaloidal salts have a tendency 

 to diminish the digestive power of papoid; a tendency which is more 

 pronounced with strychnin than with brucin, the inhibitory action 

 in the latter case being comparatively slight. Doubtless, the in- 

 crease in digestive action coincident with the increase in the per- 

 centage of the alkaloids is due to the slight acidity of the salts, 

 which presumably overcomes in part the retarding effect of the 

 alkaloidal base. 



Antipyrin and Acetanilid. 



The 10 grams of prepared raw beef contained 2*6996 grams of 

 dry proteid (110° C). 



The mixtures were warmed at 45° C. for 6|- hours. 



Medium 



We 



ght of undigested residue. 



Proteid digested 



Control 





0-9758 



gram 



63 8 per cent. 



] -0 per cent. 



Antipyrin 



0-9500 





64-8 " 



2-0 



( ( 



1-0803 





59-9 " 



4-0 



ii 



1-2992 





51-8 " 



1-0 



Acetanilid 



0-9102 





66-2 " 



2-0 



<( 



1-0497 





61-1 " 

 1 • 1 . • 



These two drugs agree in producing a very slight increase in 

 proteolytic action when present in the digestive mixture in moder- 

 ate amounts, followed in the case of antipyrin by a decreased diges- 

 tive action when the amount present reaches 4*0 per cent. 



Quinine Sulphate. 



With this salt, there is, as the results show, a slight inhibitory 

 action on the digestive power of the ferment, but not sufficient to 

 materially interfere with its proteolytic action. 



