50 G. F. Barker—Physiological Chemistry. 
ance in the urine also. If the injection be made into the gen- 
eral venous system, the amount which reaches the liver is too 
small to produce the effect ; but if introduced into the portal 
vein, all must go to the liver and exert its action. 200 grains 
sodic carbonate dissolved in an ounce of water, were injected 
into a branch of the portal vein of a dog, and the animal was 
then killed. Artificial respiration was kept up for 1} hours, 
the heart beating vigorously all the time. The urine which — 
collected in the bladder was pale and alkaline, and effervesced 
with acids, but gave no trace of sugar. The liver was also 
devoid of sugar, but became saccharine in 24hours. Dr, Pa 
then investigated the action of an alkali on the hepatine dur- 
He had long before noticed that the ingestion of po- 
tassic carbonate caused the hepatine to disappear oad ee 
from the liver ; and this without the production of su 00 
grains in two ounces of water, injected through the pee 
gus into the stomach of a dog ‘recently fed, caused the death of 
the animal within 12 hours ; no trace of hepatine or sugar ex- 
isted in the liver. If the carbonate be injected into a branch 
of the portal vein, the disappearance of the hepatine takes 
place ina proportionally shorter time. In one experiment, 
grains sodic carbonate in 64 ounces of water were injected into 
one of the mesenteric veins, and the dog was killed in one 
) iver was somewhat congested but contained 
neither hepatine nor sugar. Hence it appears that by the in- 
fluence of this salt, ther whole of the hepatine may be rapidly 
destroyed during lite, without the formation of sugar. To 
ensure success, however, in such experiments, Pavy found it 
necessary to use the ‘solution quite concentrated, and to 
throw it in rapidly ; it then seems to suspend the ‘liver cir- 
culation, and to exude into the tissue. Holding the muzzle 
of the animal so as to check his breathing, has the same effect. 
sing the cautions suggested by his experience, Pavy was able 
to cause the disappearance of the hepatine in even a few min- 
utes ; 100 eee sodic carbonate in half an ounce of water 
alcohol; the solution is still lactescent, is colored red iodine | 
and when boiled with acids or acted upon by saliva, is conver- — 
