G. F. Barker—Physiological Chemistry. 51 
ted into sugar. In the cases mentioned, however, all these tests 
faile Again, the hepatine is not cha inged into sugar by the 
alkaline carbonate ; inasmuch as, were this the fact, an ordi- 
nary liver weighing 74 lbs. and containing 7 per cent of hepa- 
tine, ought to vield—allowing 1} parts of hepatine to produce 
1 of sugar—over one hundred ‘and fifty grains of sugar, an 
amount “readily detected. Nor, further, is it deco mposed as 
fast as formed ; at least not by the carbonate, ‘each appears 
to have no action on sugar. 200 grains each of sodic carbonate 
and grape sugar were dissolved together in an ounce of water, 
and the solution was injected into a mesenteric vein of a good- 
sized dog. ood afterward drawn from the carotid was sac- 
charine; and in half an hour when the animal was killed, both 
the liver and the blood contained sugar. The urine was bloody 
/ —as is always the case when so much sodic carbonate is in- 
}  jected—and contained sugar. Finally, the hepatine does not 
’ seem to disappear from any direct chemical action of the car- 
4 
sii ase ie al lit 
bonate upon it; since even caustic alkalies at a boiling heat 
are without effect. Pavy therefore concludes “‘ that the rapid 
pre Lens of hepatine is due to one of those rises Ay ac- 
tions of which we have such numerous examples occurring 
anaoninet the phenosens of life.” Another eenabkaitie fact 
which Pavy states is that while the post-mortem injection of 
sodic carbonate into the liver prevents the production of sugar, 
_ it does not cause the disappearance of the hepatine.. Moreover, 
in the liver of a cod-fish which he examined, the ordinary post- 
mortem production of sugar seemed to be spontaneously resis- 
ted ; no sugar appearing after 24 hours repose nor after expo- 
sure to warmth for three hours. In this liver either the he- 
{  patine was protected, as in the experiments with sodic carbon- 
; ate, or the catalytic agent was wanting to effect the change. 
Pavy also notices that after the introduction of sodic carbon- 
j ate into the liver, this organ yields on analysis a very high 
| _ percentage of fat. The usual quantity being from 4 to "6 
4, percent, Pavy’s analyses of livers after the above treatment 
showed them to contain from 10 to over 13 per cent of fat ; 
obviously establishing a close connection between hepatine and 
| fat. From the results obtained, Pavy concludes: Ist, That 
sodic carbonate introduced into the lood, prevents the pro- 
duction of saccharine urine after lesions of the sympathetic 
nerve, which otherwise occasion it. 2d, That this salt injec 
’ into the general venous system, does not prevent the cee 
condition after death when the circulation is artificially main 
tained ; but injected into the portal system so that it ee ma: 
ass into the liver, it keeps the urine free from 
That sodic carbonate when injected into the portal pee tt dur- 
