ANIMALS AFTER INOCULATION. 251 



weight. The condition of progressive emaciation just 

 mentioned is conspicuously seen after intravenous inoc- 

 ulation of rabbits with cultures of baciUus typhi ab- 

 dominalis and of baoter-ium coli commune, referred to 

 in the chapter on the latter organism, and if looked 

 for will doubtless be seen to follow inoculation with 

 other organisms capable of producing chronic forms 

 of infection, but which are frequently considered non- 

 pathogenic because of their inability to induce acute 

 conditions. Not infrequently in chronic infections there 

 may be hardly any marked and constant temperature- 

 variations until just before death, when sometimes there 

 will be a rise and at other times a fall of temperature. 

 In the majority of cases, however, one must be very 

 cautious as to the amount of stress laid upon changes 

 in weight and temperature, for unless they are progres- 

 sive or continuous in one or another direction they may 

 have little or no significance as indicating the existence 

 or absence of disease. 



