286 BACTERIOLOQY. 



their tissues of increasing amounts of virul A\t strepto- 

 cocci. 



A great deal has been said both for a: i against the 

 claims of Marmorek ; but at present the bulk of 

 opinion is unfavorable, or at most very conservative. 

 Many competent clinicians look with favor upon the 

 use of this serum in suitable cases — i. e., genuine, un- 

 complicated streptococcus infections; but at the same 

 time others have failed to demonstrate its usefulness. 

 Koch and Petruschky failed throughout to confirm 

 Marmorek's results. It is difficult to reconcile the fact 

 that a single or even several attacks of erysipelas or of 

 phlegmonous inflammation in the human being afford 

 no protection from subsequent attacks, with the state- 

 ment of Marmorek that a condition of complete im- 

 munity may be established in animals by the repeated 

 induction of mild manifestations of the disease. 



Streptococcus pyogenes is the organism most com- 

 monly found in rapidly spreading suppuration, while 

 staphylococcus pyogenes aureus is most frequently found 

 in circumscribed abscess-formations; they may also be 

 found together. 



Note. — If the opportunity presents, obtain cultures 

 from a case of erysipelas. Compare the organism thus 

 obtained with the streptococcus just mentioned. Inoc- 

 ulate rabbits both subcutaneously and into the circula- 

 tion with about 0.2 c.c. of pure cultures of these organ- 

 isms in bouillon. Do the results correspond, and do they 

 in any way suggest the results obtained with staphylo- 

 coccus pyogenes aureus when introduced into animals in 

 the same way ? Do these streptococci flourish readily 

 on ordinary media? 



