288 BAOTERIOLOar. 



infiltration of the tissues about a fracture, in purulent 

 cerebro-spinal meningitis, in suppurative synovitis, in 

 acute pericarditis, and in acute inflammation of the 

 middle ear. 



Moreover, many of the less common organisms have 

 been detected in pure cultures in inflammatory condi- 

 tions with which they were not previously thought to 

 be concerned, and to which they are not usually related 

 etiologically. 



In consideration of such evidence as this it is plain 

 that we can no longer adhere rigidly to the opinions 

 formerly held upon the etiology of suppuration, but 

 must subject them to modifications in conformity with 

 this newer evidence. We now know that there exist 

 bacteria other than the " pyogenic cocci," which, though 

 not normally pyogenic, may give rise to tissue-changes 

 indistinguishable from those produced by the ordinary 

 pus-organisms.^ 



GONOCOCOUS. MICEOCOGGTJS GONOEEHOE^. 



One observes upon microscopic examination of cover- 

 slips prepared from the pus of acute gonorrhoea that 

 many of the pus-cells contain within their protoplasm 

 numerous small, stained bodies that are usually arranged 

 in pairs. Occasionally a cell is seen that contains only 

 one or two pairs of such bodies ; again, a cell will be 

 encountered that is packed with them. Occasionally 

 masses of these small bodies will be seen lying free in 

 the pus. (See Fig. 58.) The majority of the pus-cells 

 do not contain them. 



^ For a more detailed discussion of tlie subject, see "The Factors Con- 

 cerned in the Production of Suppuration," International Medical 

 Magazine, Philadelphia, May, 1892. 



