296 SACTERIOLOOY. 



In man typical gonorrhtt'a has been produced on 

 several occasions by the introduction into the urethra 

 of pure cultures of this organism. 



In addition to its causal relation to specific ure- 

 thritis, it is the cause of gonorrhoeal prostatitis in 

 man, of gonorrhoeal proctitis in both sexes, and of gon- 

 orrhoeal inflammation of the urethra, of Bartholin's 

 glands, of the cervix uteri, and of the vagina in 

 women and young girls. It is etiologically related to the 

 specific conjunctivitis (ophthalmia neonatorum) of young 

 infants, and also occasionally to ophthalmia in adults. 



Secondarily, it is concerned in specific inflammations 

 of the tubes and ovaries, of the lymphatics communi- 

 cating with the genitalia, of the serous surfaces of joints, 

 and of those of the heart, lungs, and abdominal cavity. 



Other species of micrococci have from time to time 

 been described as occurring in the pus of acute urethritis 

 and of other purulent inflammations. Many of these 

 are of no significance. Some of them possess peculiarities 

 that might lead to confusion. The diplococcus described 

 by Heiman' has certain points of resemblance to the 

 gonococcus, such as its location in the bodies of pus- 

 cells, its grouping as diplococci, its size and general ap- 

 pearance ; but it is still readily distinguished from the 

 gonococcus by its retention of color when stained by 

 Gram's method. The diplococcus detected by Bumm 

 in puerperal cystitis is likewise often found within pus- 

 cells; but it is readily differentiated from the gono- 

 coccus by its growth upon ordinary nutrient media. 

 Dlploaoccus intracellularis meningU'uJh of Weichsel- 

 baum, isolated from the pus of cerebro-spinal menin- 

 gitis, is microscopically also strikingly like the gono- 



1 New York Medical Eecord, June 22, 1895. 



