tHE BACILLUS OF GLANDERS. ?u7 



verted into indurated, knotty cords — "fercy-buds" — 

 easily discernible from without. 



In man it usually occurs in individuals who have 

 been in attendance upon animals affected with the dis- 

 ease. It may occur upon the mucous membrane of the 

 nares ; but its most frequent expressions are in the skin 

 and muscles, where appear abscesses, phlegmons, ery- 

 sipelas-like inflammations, and local necrosis closely 

 resembling carbuncles. Metastases to the lungs, kid- 

 neys, and testicles, as in the horse, may also be seen. 



When occurring upon the raucous membrane glan- 

 ders is characterized by the presence of gray nod- 

 ules, about as large as a pin-head, that closely re- 

 semble miliary tubercles in their naked-eye appearance. 

 These consist histologically of granulation-tissue — i. e., 

 of small round cells, very similar to proliferating 

 leucocytes — of some lymph-cells, and, in the earliest 

 stages, of a small portion of necrotic tissue. As they 

 grow older, and the process advances, there is a 

 tendency to central necrosis, with the ultimate for- 

 mation of a soft, yellow, creamy, pus-like material. 

 Though strikingly like miliary tubercles in certain 

 respects in the early stages, they present, nevertheless, 

 decided points of difference when examined more in 

 detail. 



The round-cell infiltration of the glanders nodule con- 

 sists essentially of polymorphonuclear leucocytes, while 

 that of the miliary tubercle partakes more of the nature 

 of a lymphocytic infiltration ; in the later stages of the 

 process the glanders nodule breaks down into a soft, 

 creamy matter, very analogous to ordinary pus, while 

 in the later stages of the miliary tubercle the tendency 

 is to an amalgamation of its histological constituents. 



