378 BACTERIOLOGY. 



and ultimately to necrosis with caseation. The giant- 

 cell formation common to tuberculosis is never seen in 

 the glanders nodule. As Baumgarten aptly puts it : 

 " The pathological manifestations of glanders, from the 

 histological aspect, stand midway between the acute 

 purulent and the chronic inflammatory processes." ' 

 Evidently these differences are only to be explained 

 by differences in the nature of the causes that underlie 

 the several affections. We have studied the character- 

 istics of bacillus tuberculosis ; we shall now take up the 

 bacillus of glanders and note the striking differences 

 between them. 



THE BACILLUS OF GLANDERS (bACILLTJS MALLBI). 



In 1882 Loffler and Schiitz discovered in the diseased 

 tissues of animals suffering from glanders a bacillus that, 

 when isolated in pure culture and inoculated into sus- 

 ceptible animals, possesses the property of reproducing 

 the disease with all its clinical and pathological mani- 

 festations. It is therefore the cause of the disease. 



This organism is a rod, with rounded or slightly 

 pointed ends. It usually stains somewhat irregularly. 

 (See Fig. 67.) When examined in stained prepara- 

 tions its continuity is marked by alternating darkly 

 and lightly stained areas. It is usually seen as a 

 single rod, but may occur in pairs, and less frequently 

 in longer filaments. 



The question as to its spore-forming property is still 

 an open one, though the weight of evidence is in oppo- 



' For a further discussion of the pathology and pathogenesis of this 

 disease, see Lehrbuch der pathologischen Mykologie, by Baumgarten, 

 1890. See, also, Wright : "The Histological Lesions of Acute Glanders 

 in Man," Journal of Experimental Medicine, vol. i. p. 577, 



