21 



•abnormal in the west, would be allowed to reach without condemnatioh 104.4°, 

 a pqint entirely outside of the normal range. ' ' 



Other things being equal, 103° Fahrenheit would appear to indicate the 

 danger line, but no fixed rule can possiibly be adopted, close observation arid 

 sound judgment i'n the operator being of more importance than hard and fast 

 , ruling. 



The thermal rise is accompanied, or rather followed, by a hard, tense and 

 exceedingly painful swelling at the point of injection. Thi.s swelling is usually 

 circular, and shows a tendency to increase from the eightlj' hour after injection, 

 at the same time becoming more painful, affecting the muscles and causing . 

 marked lameness in the forelimb of the side on which the injection was made. 

 It is often accompanied by swelling of the surrounding lymphatics, which also 

 become intensely painful. 



The local reaction does not, as a rule, entirely disappear for several days. 



Besides the thermal and local reactions Mallein produces well marked 



constitutional effects on animats suffering from Glanders. The pulse and 



rcspisation are increased, rigors are frequent, sometimes slight, but occasionally 



\ yioMit, and continuing throughout the whole reaction. There is great depres- 



( sioiy while loss of -appetite, staring cqat, and disinclination to move ai-e also 



commonly noted. 



In clinical cases reaction is, as a rule, early and well marked, and most of 

 -our inspectors agree that the severity of the reaction i^ in direct ratio to the 

 degree of infection or the stage which the disease has reached. Clinical 

 symptorns not unfrequently make their first appearance during the test, gener- 

 ally from 24 to 30 hours after injection. In advanced cases they may persist, 

 the animal' rapidly breaking down, while in incipient cases they may gradually 

 recede, the animal regaining a normal and comparatively healthy appearance. 

 Clinical symptoms already evident are almost invariably aggravated by the 

 test. Oiie especially noteworthy feature is that in animals showing only a 

 slight enlargement of the submaxillary lymphatic glands, these will become 

 tense, swollen and painful as the, test progresses. This also'appHes to other 

 enlarged nodes. Dr. Moore describeis one case in which both inguinal glands, 

 slightly enlarged before the test, became, during its progress, so much swollen 

 and so painful that the animal could scarcely walk. Post mortem revealed 

 specific lesions in both glands. 



Occasionally all evidences of reaction are present, except the thermal risci 

 while in others the opposite is, the case, and it may be noted that these eccen- 

 tricities are not unfrequently shown by all the horses tested in certain outbreaks, 

 and further that they persist throughout repeated tests of the same animals, 

 altho>ugh, under ordinary conditions, the Ibcal reaction has. a tendency to 

 become less well mjyked with each succeeding test. 



In animals in the lasit stages of Glanders,' old horses, young foals,' and - 

 others of inferior vitality, a lowering of temperature not unfrequently follQws 

 the injectidn of Mallein. This is especially noticeable in advanced cases where 



