VIIl] 



MICROCOCCI 



159 



I have inoculated a number of white mice subcutaneously 

 in the tail with a small micrococcus, due to accidental 

 contamination. These micrococci, having been cultivated 

 through several generations, were used in small doses for 

 the inoculation of the mice. In two instances the 

 inoculation was followed after two or three days by puru- 

 lent inflammation at the seat of inoculation, but apparently 

 not spreading beyond it. But, as time went on, inflam- 

 mation and abscess in the lungs set in and the animals 



Fig, 39, — From a Section through the Tail of a Mouse inoculated into 

 THE Subcutaneous Tissue of the Tail with artificially cultivated 

 Micrococcus, 



The part here illustrated is a good distance from the ulceration, 



1, A capillary blood-vessel filled with blood-corpuscles, 



2, Fat cells. 



3, Groups of micrococci filling the lymph-spaces of the connective tissue. 



died after about a week. On making longitudinal sections 

 through the tail, it was found that in most of the lymph- 

 spaces and lymph-vessels of all parts of the cutis and 

 subcutaneous tissue, far away from the seat of inflammation, 

 there were densely crowded masses of the same minute 

 micrococci as were used for inoculation. And these crowds 

 of micrococci could be traced to the seat of inflammation, 

 where they extended amongst the inflammatory products in 

 great masses. The abscesses in the lungs were filled with 



