222 MICRO-ORGANISMS AND DISEASE [chap. 



covery show themselves refractory against inoculation with 

 material of the diseased lung or intestine. 



Inoculations into guinea-pigs with material from the 

 diseased swine produce at the seat of inoculation hsemor- 

 rhagic infiltration and thickening, sometimes leading to death 

 in two or three days ; often, however, the thickening passes 

 off in a week or so ; cultures injected subcutaneously in 

 guinea-pigs produce thickening at the seat of inoculation, 

 but rarely death. 



Inoculation into mice of minute particles of material of 

 the diseased lung, or intestine, or of gelatine, or broth cul- 

 ture of the bacillus of swine fever causes disease and death 

 in four to eight days ; the spleen is found enlarged and 

 dark ; the liver is mottled with grey dots, streaks, and patches 

 of necrotic tissue ; the peritoneum is inflamed, and so are 

 the kidneys and both lungs. Cover-glass specimens and 

 cultures from the heart's blood and liver, kidney, and parti- 

 cularly the spleen, demonstrate the presence of large num- 

 bers of the bacilli {see Fig. 76). Among the bacilli in the 

 spleen numerous long cyhndrical rods can be seen. In the 

 kidneys many of the capillaries of the glomeruli are plugged 

 by the bacilli, so also in the liver. 



In the rabbit inoculation produces disease and death in a 

 few days : the spleen is slightly enlarged, the lungs. are in- 

 flamed, the kidney is much congested in the cortex. Here 

 also the bacilli can be easily demonstrated in the heart's 

 blood, the liver, and the kidney ; in this latter many Mal- 

 pighian corpuscles show the capillaries of the glomeruli 

 plugged with masses of the bacilli. 



8. Badlhis of Wildseuche. — A disease amongst cattle 

 (Rinderseuche) and horses, and amongst deer (Wildseuche), 

 manifesting itself in diffuse pneumonia and hEemorrhagic 

 enteritis, but without necrotic change (consolidation and 



