XIll] MICROBES OF MALIGNANT ANTHRAX 309 



chest of the inoculated side ; the inguinal glands of the 

 inoculated side are deeply congested. The lungs are 

 congested, sometimes more, sometimes less ; sometimes the 

 greater part of one lobe or another is deep purple ; pleuritis 

 and pericarditis are often found ; the liver is slightly or not 

 at all congested, is even pale ; the spleen is not enlarged ; 

 the serous covering of the stomach and intestines is con- 

 gested ; the suprarenals are deep red ; the kidney is con- 

 gested in the medullary part. Neither from the heart's 

 blood nor from the lung, liver, spleen, or kidney can as a 

 rule any organisms be cultivated, but occasionally the lungs 

 and the omentum yield positive results ; from the sub- 

 cutaneous tissue of the inoculated part, particularly from 

 the congested inguinal glands, the bacilli can be obtained 

 in pure cultivations, some tubes showing a limited number 

 of colonies, others showing them abundantly ; but not in all 

 animals is the culture test successful, though in most it is so. 

 While guinea-pigs> are very susceptible to subcutaneous 

 inoculation, they show considerable resistance to in- 

 traperitoneal injection. It has been mentioned in a 

 former chapter (Chapter vii.) that, while a number of 

 species of bacteria possess in their protoplasm substances 

 which act poisonously on the animal body (protein poisons, 

 intracellular poisons) when introduced in sufficient doses as 

 bacterial bodies, living or sterilised, into the peritoneal 

 cavity — e.g., vibrio of Finkler and cholera, bacillus pro- 

 digiosus, bacillus coli and typhosus, proteus vulgaris, 

 &c. — causing acute fatal peritonitis, and while further 

 some notoriously pathogenic bacilli — e.g., anthrax, fowl 

 cholera, and diphtheria — do not contain these intracellular 

 poisons, at any rate large doses of the bacterial bodies 

 (sterilised) can be injected intrapei'itoneally without pro- 

 ducing the acute fatal peritonitis. Now it is a strange fact 



