xiil] MICROBES OF MALIGNANT ANTHRAX 313 



grey, consolidated, lobular patches, and the kidneys are 

 always enlarged and white ; on a section the whole cortex is 

 found to be fatty degenerated, while the medulla shows con- 

 gestion. Further, I have ascertained that an infectious 

 disease with the same symptoms and leading to the same 

 result exists naturally amongst cats ; the animals have severe 

 lung trouble, emaciate, and die with the same pathological 

 appearances, notably on the part of the kidney. In one case 

 I have seen such a cat after several weeks' illness showing 

 paresis of the hind extremities. 



When cats are inoculated subcutaneously in the groin 

 with a particle of human diphtheritic membrane they 

 become very ill, show already after twenty-four hours a 

 painful swelling in the groin, have high temperature, and 

 refuse food. In the severe cases these symptoms increase 

 in intensity during the next days, and the animals die before 

 the end of the week. On post-mortem examination the 

 subcutaneous and muscular tissue at and near the seat of 

 inoculation are found to contain hemorrhage and oedema, 

 and the tissue is separated into layers, which are more or less 

 necrotic. The viscera show much congestion, particularly 

 the lungs, also the serous covering of the stomach and 

 intestine as well as the peritoneum ; the kidney is large and 

 white, the medulla congested, while the cortex is more or 

 less uniformly fatty. This condition is more marked the 

 longer the illness ; when the animals die in three to four 

 weeks, or later, the condition of the kidney is very striking, 

 and then also the lungs show lobular patches of grey 

 consolidation. Still more striking is the result when a small 

 quantity, i cc, of a virulent culture of our bacillus diph- 

 therife is subcutaneously inoculated. If a fresh culture — 

 one twenty-four to forty-eight hours old— is used, the 

 animals are very ill already after twenty-four hours : they 



