Xiv] BACILLUS TUBERCULOSIS 335 



spleen, which is enlarged, we find already numbers of 

 minute granules projecting above the surface of the capsule, 

 thus making the surface uneven and rough. In the liver 

 there are numerous minute, gray, punctiform nodules, which 

 in some places have a tendency to confluence ; on section 

 grayish streaks are recognised under a glass between the 

 normal red liver tissue ; the whole organ is slightly en- 

 larged. The omentum shows also numerous minute opaque 

 patches, which are only more numerous and larger than 

 those normally found. The lymph glands in the porta 

 hepatis are large and firm, so also those in the hilum of the 

 spleen ; the mesenteric glands are large and firm. In the 

 marrow of long bones gray and even caseous tubercles 

 can be distinguished. If the animal is allowed to live, it 

 will be found gradually getting thinner towards the third or 

 fourth month ; it dies generally not before the end of the 

 third or later than the end of the fifth month, the average 

 duration being 100 to 120 days after inoculation. 



Rabbits inoculated subcutaneously in the inguinal region 

 with human tubercular sputum show very much less pro- 

 nounced disseminated tuberculosis than guinea-pigs ; after 

 many weeks — twelve to sixteen or more weeks — the animal 

 is found much emaciated ; the lymph glands of the inguinal 

 region enlarged, caseous ; in the lungs few or no tubercles, 

 in the liver a few tubercles, some gray, others yellow ; the 

 spleen is enlarged and contains many tubercular deposits ; 

 the mesenteric and other abdominal lymph glands swollen, 

 firm, caseous ; the process, on the whole, is very distinctly 

 less intensive and extensive than in the guinea-pigs. I 

 have seen numerous cases in which, after twelve to sixteen 

 weeks, the only organ containing numerous tubercles was 

 the spleen, the liver contained only few, the lungs none. 



Feeding guinea-pigs and rabbits on human tubercular 



