336 MICRO-ORGANISMS AND DISEASE [chap. 



matter produces tuberculosis, but with this difference, that 

 while in the guinea-pig it leads to general disseminated 

 tubercular deposits, it is far less so in the rabbit. In the 

 guinea-pig, if the animal be killed after six to eight weeks, 

 we find distinct tubercular deposits in the wall of the small 

 intestine, the tubercles are situated in the Peyer's glands of 

 the ileum and ileo-csecal valve, are of various sizes, and 



Fig. i2g. — From a Preparation of Human Tuberculous Sputum, stained 



AFTER THE EhRLICH-WeIGERT MetHOD. 



Nuclei and the tubercle-bacilli. Magnifying power 700. 



more or less caseous in the centre ; the mesenteric glands 

 are always enlarged and contain firm caseous deposits. The 

 liver also shows already grey tubercular nodules and streaks, 

 the spleen is slightly enlarged and granular. The whole 

 process, judging from the amount and progress of the 

 changes, started in the lymphatic follicles of the ileum and 

 spread from here into the mesenteric lymph glands, liver 

 and spleen. The lungs show by this time no tubercles yet. 



