Xiv] BACILLUS TUBERCULOSIS 341 



in the milk gland. In this latter, the condition assumes an 

 important practical aspect, since the udder of a cow may 

 contain tubercular nodules without these being easily 

 diagnosed, and which may give to the milk infective pro- 

 perties. Although in light cases the milk gland is found 

 free of tubercles, yet in many advanced cases purulent 

 tubercular deposits have been demonstrated in the udder. 



In the lymph glands, spleen, and liver, the character of 

 the nodules is the same as in the lung, and giant cells form 

 a very conspicuous feature. 



Infection with general tuberculosis of guinea-pigs and 

 rabbits by bovine tubercular matter, both by feeding and sub- 

 cutaneous inoculation, is easily achieved ; the result is more 

 intense and much more rapid than by infection with human 

 tubercular matter. Guinea-pigs subcutaneously inoculated 

 develop disseminated tuberculosis of the lymph glands, 

 lungs, liver, spleen, serous membranes, and marrow of bone 

 in less than half the time ; in some cases the animals die in 

 about five to six weeks with remarkably widespread and 

 advanced tubercular deposits. Also as regards rabbits, the 

 process is much more rapid and more intensive ; for while 

 these animals, as mentioned above, after inoculation with 

 human tubercular matter, develop, as a rule, only a more or 

 less mild form of tuberculosis, hmited chiefly to some lymph 

 glands, spleen, and perhaps the liver, after inoculation with 

 bovine tubercular matter they show very numerous tubercular 

 deposits in the lungs, liver, and spleen, all lymph glands, 

 and even the kidneys. The same results are obtained 

 by feeding rabbits and guinea-pigs with bovine tubercular 

 matter. Here also the process starts with tubercles of the 

 ileum, then spreads to the mesenteric glands, the pelvic 

 glands, the omentum, spleen, and Hver, and finally the 

 lungs and sternal and bronchial lymph glands. The differ- 



