524 MICRO-ORGANISMS AND DISEASE [chap. 



appearance is found, not only in the epithelium of cancer 

 but in many other normal or pathological conditions of 

 epithehum. There is nothing to distinguish these small 

 bodies from leucocytes. 



(c) Small and large particles, vacuoles singly and in 

 clusters, situated in a more or less distinct cavity in the 

 cell substance. They occur singly or several together in 

 an epithelial cell ; but similar cell enclosures occur in 

 many other epithelial structures besides those of cancer, 

 and the fact that they occasionally stain differently from the 

 main cell substance may merely indicate a chemical change 

 which this part of the cell substance has undergone : it is 

 not a proof of their being spores of parasites. 



(d) Encysted nucleated epithelial cells. These are not 

 uncommon in cancer epithelium, but they also occur in 

 other epithelial structures. The envelope is not a real 

 capsule, but owes its origin to a separation and shrinkage 

 of the main part of the protoplasm around the nucleus, 

 whereby a peripheral part remains detached and resembles 

 a capsule. Further, in epithelial cells in which the central 

 part has undergone a hyaline change (hydrops, colloid), the 

 nucleus of the epithelial cells is pressed to the side. 



(e) Nuclear well-defined bodies, containing one or even 

 several small granules, with, in the periphery next to the 

 surrounding membrane, a more or less distinct radial 

 striation. These bodies are nuclei of epithelial cells, the 

 epithelial cell substance having become destroyed and the 

 nucleus become swollen and hydropic. The granules and 

 striae are remnants of chromatin. Such bodies occur not 

 only amongst the epithelial cells of cancer, but also in 

 other rapidly growing epithelium. 



(/) Nuclear bodies situated within the epithelial cell 

 next to the normal nucleus ; the latter slightly swollen and 



