316 BACTERIOLOGY. 



verted into indurated, knotty cords — "farcy buds" — 

 easily discernible from without. 



When occurring in man it is usually in individuals 

 who have been in attendance upon animals affected 

 with the disease. It may occur upon the mucous 

 membrane of the nares, but its most conspicuous ex- 

 pressions are in the skin and muscles, where appear 

 abscesses, phlegmons, erysipelas-like inflammations, and 

 local necrosis closely resembling carbuncles. Metas- 

 tases to the lungs, kidneys, and testicles, as in the horse, 

 may also be seen. 



When occurring upon the mucous membrane glan- 

 ders is characterized by the presence of small gray 

 nodules, about as large as a pin-head, that closely 

 resemble miliary tubercles in their naked-eye appear- 

 ance. These consist histologically of granulation tissue — 

 i.e., of small round cells, very similar to proliferating 

 leucocytes, of some lymph-cells, and, in the earliest 

 stages, of a small portion of necrotic tissue. As they 

 grow older, and the process advances, there is a ten- 

 dency toward central necrosis, with the ultimate for- 

 mation of a soft, yellow, creamy, pus-like material. 

 Though strikingly like miliary tubercles in certain 

 respects in the early stages, they present, nevertheless, 

 decided points of difference when examined more 

 minutely. 



The round-cell infiltration of the glanders nodules 

 consists essentially of polynuclear leucocytes, while 

 that of the miliary tubercle partakes more of the 

 nature of a lymphocytic infiltration; in the later 

 stages of the process the glanders nodule breaks down 

 into a soft creamy matter, very analogous to ordinary 

 pus, while in the later stages of the miliary tubercle 



