THE BACILLUS OF GLANDERS. 317 



the tendency is toward an amalgamation of its histo- 

 logical constituents, and ultimately to necrosis with 

 caseation. The giant-cell formation common to tuber- 

 culosis is never seen in the glanders nodule. As 

 Baumgarten aptly puts it: "The pathological mani- 

 festations of glanders, from the histological aspect, stand 

 midway between the acute -purulent and the chronic in- 

 flammatory processes. ' ' ' Evidently these differences are 

 only to be explained by differences in the nature of the 

 causes that underlie the several affections. We have 

 studied the characteristics of bacillus tuberculosis ; we 

 shall now take up the bacillus of glanders and note the 

 striking differences between them. 



The Bacillus of Glanders {bacillus mallei). — In 

 1882 Lceffler and Schiitz discovered in the diseased tis- 

 sues of auimals suffering from glanders a bacillus that, 



when isolated in pure culture and inoculated into sus- 

 ceptible animals, possesses the property of reproducing 

 the disease with all its clinical and pathological mani- 

 festations. It is therefore the cause of the disease. 



1 For a further discussion of the pathology and pathogenesis of this disease 

 see Lehrbuch der pathologischen Mykologie, by Baumgarten, 1890. See, also, 

 Wright : The Histological Lesions of Acute Glanders in Man. Journal of Ex- 

 perimental Medicine, vol. i. p. B77. 



