General Diseases, 349 



afterwards I heard from the owner that the favourite and 

 valuable old dog was dead. This breed of bull-dogs is, I 

 believe', now almost extinct ; they have been bred in-and-in. 



" The examination of liver and heart led to the detection 

 of a very unusual morbid change. The liver was dark ^n 

 colour, speckled here and there with yellow granules. In 

 form, the gland was almost globular ; in texture it was 

 compact, with the consistency of an ordinary fatty tumour. 

 On section the cut surface was granular, and mottled with 

 minute yellow specks. A small portion of the enlarged 

 organ was examined under the quarter-inch objective, and 

 the liver-cells were observed to be filled with globules of 

 fat. In addition, there was a considerable quantity- of 

 deposit of the nature of tubercle. 



" The heart was also much enlarged ; the cavities pf both 

 ventricles were distended with coagulated blood. The walls 

 were reduced in thickness to at least one half ; and, under 

 the microscope, the fibres were seen to be in the transition 

 state between the nucleated cell form of the fcetal struc- 

 ture and the striated character of the fully developed 

 muscle. Between the fibres there was a deposit of granular 

 matter, identical in appearance with that observed in the 

 liver. From the history of the case, there is good reason 

 to believe that the puppy was the subject of scrofula, the 

 result of hereditary transmission, intensified, and probably 

 primarily induced, by the system of in-and-in breeding. 

 The peculiar feature of the case is the existence of the 

 deposit in the liver and heart— organs which are not ordi- 

 narily affected to any serious extent in tuberculosis. The 

 lungs, spleen, and kidneys were free from disease."* 



GLANDERS. 



Fortunately, this scourge of horseflesh is but seldom met 



with in the dog. ^ - 



* From the Veierinarian, November, 1881. 



