General Diseases. 351 



no doubt as to the nature of the malady, which appeared 

 in a most acute form. 



" Polli, of Milan, has induced the disease in dogs by depo- 

 siting the virus in wounds or injecting it into the circula- 

 tion. The effects were always apparent, but their intensity 

 and gravity varied according to the mode of introduction. 

 Prinz, Andral, Burguieres, Letenneur, Leblanc, Rayer, 

 Saussier, and St. Cyr* have obtained results similar to those 

 of Renault ; Lafosse has also several times successfully 

 inoculated dogs with the glanders and farcy virus ; and 

 Decroix, from the result of his ejfperiments, came to the 

 conclusion that acute and chronic glanders are transmissible 

 to the carnivora by inoculation.t 



" Some of the large carnivora, such as the lion, have re- 

 ceived the disease through consuming the flesh of glandered 

 horses." 



* " The results of inoculations practised upon seven dogs with glander 

 matter, by Saint Cyr, of the Lyons Veterinary School, are summed up 

 as follows : — 



" I. Glanders is not the exclusive appanage of solipeds. 



"2. It can certainly be transmitted to other animals, and especially 

 to the dog, by inoculation. 



" 3. In the dog, as in the horse, it manifests itself by inflammation 

 and ulceration of the inoculated wound, swelling of the lymphatic 

 glands in its vicinity, and nasal discharge. Chancrous ulcers are, if 

 not always, at least generally, absent. 



"4. Glanders in the dog is generally remarkably benignant, and, ex- 

 cept m those cases in which it has been injected into the circulation, it 

 is perhaps seldom fatal. 



"5, Notwithstanding this marked benignity of 'canine glanders,' the 

 virus none the less preserves all its activity, and, when retransmitted to 

 the horse, inevitably produces the malady in as marked a form as when 

 passed direct from horse to horse. 



"6. -Lastly, glanders in the dog, as in the horse, appears to be 

 governed by the ' law of unicity ;' for with the horse actually glandered, 

 and the dog successfully inoculated for the first time, inoculation with 

 the most active glander virus produces no effect. This conclusion, 

 however, requires more experiments to corroborate it."— "Journal de 

 Mdd. vet. de Lyon," 1866, p. 307. 



t "Journal de Med. V^t. Militaire," 1863. 



