§ 152. QUERCITRIN, QUERCETIN, ETC. 139 



easily dissolved. They are both very slightly soluble in cold 

 water ; quercetin even in hot. They dissolve in the Axed and 

 volatile alkalies, and in alcohol, crystallizing from the latter 

 ia yellow needles. Ferric chloride colours the alcoholic solu- 

 tions green (quercetin red, on warming) ; acetate of lead pro- 

 duces orange-red and brick-red precipitates, respectively. Bofth 

 quercitrin and quercetin reduce solutions of gold and silver salts, 

 and also alkaline-copper solution after prolonged boiling. Heat- 

 ing with mineral acida resolves quercitrin into isodulcite and 

 quercetin (Lowe contradicts this, and assert,s that water alone is 

 given off). It maybe extracted from aqueous solution by agitation 

 with amylic alcohol,^ It melts at ISC to 133°, and is insoluble 

 In benzene, petroleum spirit, chloroform, and bisulphide of 

 carbon. 



In close relation to, but not identical with, quercitrin or rutin 

 stands the viohquercUrin recently isolated by Mandelin' from 

 Viola tricolor. It was deposited in yellow aeicular crystals on 

 saturating the aqueous solution with benzene. Boiling with 

 dilute acids decomposed it with production of glucose, quercetin, 

 and a third body as yet not further investigated. 



A body alUcd to quercetin appears to occur in the rhizome of 

 Podophyllum peltatum.^ According to Podwissotzky, the other 

 important constituents of this drug are podopkyllolosin, which 

 melts at 115° to 120"j is sparingly soluble in water, soluble in 

 ether and chloroform, and precipitated from chloroformic solution 

 by petroleum spirit; jwcrqpotZopAyKtra, which is easily crystallizable, 

 and soluble in 95 per cent, spirit, ether and chloroform, but 

 insoluble in milk of lime and ammonia ; and podophyUie acid, 



Gentisin is said to require 2,000 parts of cold ether for solution, 

 and must therefore be looked for in the alcoholic extract. It forms 

 pale yellow silky needles, which can be partially sublimed without 

 decomposition, requires 5,000 parts of cold, 3,850 of hot water, 

 455 of cold and 62-5 of hot absolute alcohol for solution. Feme 



' Compare Johanson, ' Zur Kenntnias einzelner cbemischer Bestandtheile 

 der Weiden,' etc. Archiv d. Pharm. [3], xlii. 110, 1878 {Fbscrm. Joum. and 

 Trans. [3], viii: 69). For Lowe's paper see Zeitschr. f. ana!., Cbemie, xiv. 

 238, 1875 (Joum. Chem. Soc. xxix< 108). See also Liebermann and Ham- 

 burger, Ber. d. d. chem. Ges.' xii. U78. 1879 (Journ. Chem. Soo. xxxvi, 9U). 



2 Sitz-Ber. d. Dorpater Naturforsoher. Ges. 1882, p. 343. 



' Compare Podwissotzky;, Archiv f. Pharm. und exper. Pathologie, 29, 1880 

 (Pharm. Joum. and Trans. [3], xii. 217, 1011). 



