264 Veterinary Medicine. 



yellowish contents. The mesenteric glands, liver and spleen 

 were enlarged, softened and ecchymosed. In all the lesions 

 coccidia were found. In the cases reported by Hess, Zschokke, 

 Guillebeau and Cadeac the abomasum and large intestine princi- 

 pally suffered. There was a diffuse inflammation of the mucosa 

 and in the rectum and portion of the colon a great degeneration 

 and desquamation of the epithelium. The columnar cells of the 

 mucous glands especially suffered. A single cell would contain 

 five or six psorosperms, in different stages of development. If 

 the parasites have escaped, the cell walls are pressed together. 

 Among the diseased glands others with healthy epithelium were 

 found, their orifices plugged with mucus. Both forms of coccidia 

 above described are found in two conditions, in the epithelial 

 cells with granular nuclei staining in haematoxylon, and violet 

 or black with iodine (L/ugol's), and outside the cells with granular 

 nucleus or simple hyaline contents which do not stain. Zschokke 

 considers the latter as in process of degeneration. Other organs 

 are anaemic. 



Symptoms. The disease is ushered in by cold extremities, 

 weakness, dullness, suspended rumination, ardent thirst, hyper- 

 thermia, 102 to 104 and even 106°, small, weak thready pulse 

 beating 100 to 140 per minute, sunken eyes, grinding of the 

 teeth, and defecation in small quantity only. Toward the fourth 

 day or earlier a foetid diarrhoea sets in, watery, bloody and fibri- 

 nous. The bloody discharges last to the seventh day, the 

 diarrhoea to the end of the second or fourth week. Straining 

 may be violent, exposing or everting the irritated or ulcerated 

 rectum, the hind parts may be stiff, the patient rises with diffi- 

 culty, he winches if pressed on the back or right side of the 

 abdomen, loses flesh rapidly and becomes a walking skeleton, 

 when the discharges are less profuse cylindroid croupous casts 

 are sometimes expelled. 



Course. Duration. In the weak and young a violent attack 

 may prove fatal in 24 hours. In others the malady lasts for two 

 or more weeks and sometimes relapses, and the patient becomes 

 very weak and anaemic. Complications of various kinds may 

 also supervene and cut off the animal, the lesions and debility 

 alike favoring the introduction of the germ. Thus black quarter, 

 bronchitis, pneumonia, convulsions, paralysis, phthiriasis and 

 ring-worm have been noted as sequelse. 



