Hcemoglobincemia. — Azotemia, Etc. 461 



During the violence of the attack there is no disposition nor 

 leisure to eat, but when the more violent symptoms abate appetite 

 is usually manifested. There may be more or less paresis of both 

 bowels and bladder, so that neither faeces nor urine is passed, 

 yet in other cases both are discharged spontaneously. 



The senses are preserved, excepting in the case of the affected 

 muscles and the integument which covers them. There may, 

 however, be more or less dullness and stupor in certain cases from 

 poisoning of the cerebral centres by the poisons circulating in the 

 blood. 



Mild Cases. In the mildest cases there is stiffness and lame- 

 ness in one, or less frequently in both hind limbs, coming on 

 when put to work after a period of idleness, and not associated 

 with any appreciable lesion of the limb in question. There may 

 or may not be hardness and swelling of the gluteal or other 

 muscles of the quarter or loins. This has the appearance of 

 rigidity or spasm but may be primarily due to cedema or exuda- 

 tion into the substance of the muscle. In some instances the 

 muscles of the breast, shoulder, or forearm are the seat of the 

 trouble. Muscular trembling and perspiration may be present 

 and if the urine is examined, it is often found to be glairy, or 

 charged with urea, and allied nitrogenous products. These cases 

 are not benefited by local applications, but they recover (tempo- 

 rarily) under rest and above all under active eliminating treatment. 

 Under gentle and progressive exercise too they improve and get 

 well. They recur, however, with great readiness under a rich 

 nitrogenous diet and a temporary rest followed by sudden exer- 

 tion. 



Between the mildest and gravest cases there are infinite grada- 

 tions of severity, one-third to one-half of the worst cases usually 

 terminating fatally, whereas the mildest are always amenable to 

 treatment. 



Progress. The course of the disease depends on the severity of 

 the attack but also, in no small degree, on the good judgment of 

 the driver. Cases that develop with great suddenness, and ap- 

 parently with extreme severity may subside spontaneously if the 

 animal is placed in a condition of absolute rest. If, however, we 

 can secure rest of the muscles of progression only, while the 

 breathing remains rapid and labored, improvement is unlikely, as 



