534 Veterinary Medicine. 



inated. Diseased bones, ulcers, chronic suppurations, and ca- 

 tarrhs may be done away with, and at least any further advance 

 of the degeneration arrested. Open air exercise and a green or 

 otherwise laxative diet would be indicated. The amyloid in lambs 

 fed on oats was corrected by a change of diet (Werner) . As 

 medication the alteratives, potassium iodide and potassium ar- 

 seniate have been mainly restored to. Bitters and iron may also be 

 of use to build up the strength. The latter should be given with 

 potassium bicarbonate. 



BLACK PIGMENTATION OF THE HEPATIC CELLS. 

 BROWN ATROPHY. 



In horse. With melanoma and atrophy, or without, pigment granules 

 fill hepatic cells, liver becomes brown or black. In calves. In sheep. 

 Apart from melanosis, the real cause unknown. 



The accumulation of granules of black pigment in the hepatic 

 cells has been noticed in old and worn out horses (Louis Blanc, 

 Cadeac, Briickmuller), in calves (Degive, Cadeac), and in 

 sheep (Siedamgrotzky, Barrier). In horses it has been found in 

 connection with atrophy, or in other cases, with melanotic tumors 

 in other parts. In atrophic cases the liver is small, puckered, 

 brown and dull, with a leathery appearance on section, and with 

 the hepatic cells charged with pigment granules so that each 

 acinus has a stellate appearance from the radiating lines of cells. 

 This constitutes brown atrophy. 



The second form which may be called melanotic liver, is not 

 associated with atrophy, but is characterized by the crowding of 

 the hepatic cells with black pigment granules, which fill up the 

 protoplasm and crowd the still pale nucleus to one side. The 

 affected portions become of a deep black. 



In calves the [pigmentation may be confined to the superficial 

 portion of the liver (Degive). 



In sheep pigmentation may be in the peripheral cells only of 

 the acinus (Cadeac) but is about equally distributed on the sur- 

 face, and throughout the interior of the liver, and may extend to 

 the stroma of the gland. (Siedamgrotzky). 



