176 ^•|^]F,RIN,\R^' pathology. 



or several days. Fibro-connective tissue is invariabh- the pro- 

 duct of tissue proliferation. Mhro-connective tissue prolifera- 

 tion is closely associated with chronic inflammation, in fact it is 

 almost inseparable from it. The proliferated tissue appears first 

 in the frame-work of the tissue involved and may later extend 

 into the parenchymatous tissue. If the proliferated tissue is 

 excessi\e it may, bv pressure, produce atrophv of the parenchy- 

 matous tissue. Cicatrization of the proliferated tissue causes an 

 irreijular lobulation and constriction of the involved organ, as 

 in cirrhosis of the kidney. Strictures of hollow organs are pro- 

 duced in the same way. Adhesions of serous membranes are 

 produced bv fibrous tissue formed during inflammation. 



Dissolution or dcstniciioii is a result of intense irritation. 

 Necrosis of tissue is fre(|uentlv a secpience of inflammation. A 

 single cell or only a few cells may be destroyed or large areas 

 of tissue may undergo necrosis. Ulceration results from con- 

 stant cellular necrosis. Circulation may be obstructed by an 

 intlamr.iator\- exudate and cause necrosis in large masses of 

 tissue. It may terminate fatally, in partial recovery, or in reso- 

 lution, depending upon the importance of the tissue involved in 

 the affected animal. 



Conclusion. — Inflammation is the reaction of a living tissue 

 to an irritant. 



Inflammation is a complex process, the result of many fac- 

 tors. 



It is not always a result of infection. 



It is an adaptive, reparative and protective process. 



It may produce sufficient reaction to cause destruction of 

 the portion involved and occasionally of the entire organism. 



