RETROGRESSIVE TISSUE CHANGES. 



:oi 



Of the chemic substances capable of producing- cloudy swell- 

 ing bacterial products are the most important. The diphtheria 

 toxin is probably the most active of all bacterial products in the 

 production of cloudy swelling. Other organic substances as leu- 

 comains and phenol are capable of producing this degeneration 

 as well as many inorganic sulxstances as arsenic, mercury, phos- 

 phorous and the mineral acids. 



Thermic disturbances, especially high temperature, is i)rob- 

 ably a cause of cloudy swelling. Halliburton has demonstrated 

 that certain high temperatures produce turbidity or granular 

 degeneration of cells. From experimental evidence it is appar- 

 ent that different groups of the albumins of the cell protoplasm 

 are separated (coagulated) at difTerent temperatures. The high- 

 er the temperature the more fixed the coagula and the more 

 difficult the)' are of solution. From the present known facts, 

 although the chemistry is not determined, it is evident that high 







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Fir. 111. — Cloudy Swelling, showing granular degeneration uf kidney cells 



