_M0 \i-:t];rix.\k^ patiiologv. 



verted into a fatt}- mass termed adipocere, which is no doubt 

 the result uf ferments Hberated from the dead tissue. 



Effects. — The conversion of the cell protoplasm into fat im- 

 pairs Uie cell functiLin. At least diminished cell action, as well 

 as disturbed cell metabolism is evident in cells affected with 

 pathologic fatlv change. In cells slightly affected, the droplets 

 are either oxidized or are extruded from the cell (absorjjed when 

 the cause is removedj. Cells more extensi\'clv aft'ected may be 

 destr(i}'ed, lea\-ing a lucshwork of vessels and fibrous tissue. 

 The area may later be filled with the new parenchymatous cells 

 arising from the surrounding less affected zones, and, like those 

 destroyed, it ma^• persist as a mass of fibrous tissue, i. e., a scar. 

 If regeneration occurs there must be an adequate blood supply. 



The degenerated cells ma^' become caseated as a result of 

 the conversion of the fattv material into a cheese like mass. 

 The usual cause of caseation of fatt}- debris is diminished or 

 obstructed blood supply resulting in gradual absorption of the 

 fluids, saponification of the fats and in some instances the forma- 

 tion of cholesterin. Caseated material derived from the fatty 

 debris ma}- later be liquified or calcified. 



AMYLOID CHANGES. 



Dl-riXlTlON. 



E'llOLUCV. 



Al'PEAK.INCE. 



Macroscopic. 



Microscopic. 

 TI.S'SrE ,1FI IlCTFJi—.Siihcndolhclitiw. 

 EFFECTS. 



Some masses may be found in the acini of the prostate gland, 

 especially in old dogs and aged humans, that respond to the iodine 

 test and are considered bv some authorities as amyloid bodies. 

 I']i_\-siologic amyloid formations ha\-e not been observed other 

 than in the i)roslate gland and they probably have a pathologic 

 origin. Thus a physiologic prototype of amyloid formation is 

 unknow n. 



Amyloid substance (amylin) is an albuminoid, insoluble in 

 ^\'ater, alcoliol, ether, chloroform, x^dol, dilute acids or alkalies 

 and is not acted upon by pepsin. When tissue containing amy- 

 loid substances is immersed in Lugobs solution the amyloid 

 areas assume a mahogany brown color and the normal tissue is 

 stained a yellowish brown. (To make this test wash the affected 

 tis-^ue thoroughly until all blood has been remo^'ed, apply a lib- 



