364 VETERINARY PATHOLOGY. 



little resistance and in which the disease assumes an acute 

 form. In the nasal mucous membrane, diffuse, glanderous les- 

 ions appear as severe inflammation in which the submucosa is 

 extensivelv infiltrated. The engorgement of the tissue may be 

 sufficient to obstruct circulation and result in necrosis of the 

 mucnus mem1)rane thus producing ulcers variable in size and ir- 

 regular in contour. The submaxillary lymph nodes arc invari- 

 ablv hard and enlarged and may or may not be adherent to the 

 maxilla. 



I'ulmonarv, dift'use glander lesions vary in size from a hazel 

 nut tn a basket ball and are irregular in shape. These lesions 

 are gravish nr dirtv wliite in cr)lor. The lesions may undergo 

 a central necrosis or thev may liecome fibrous in nature. The 

 necrotic material mav 1)e of a semi-solid or caseous consis- 

 tenc_\- and in the smaller foci there may be calcification. In 

 practically all cases of pulmonarv glanders the bronchial and 

 mediastinal lymph nodes are enlarged and contain cellular necro- 

 tic or fibrous centers. 



I "ifl-use cutaneous lesions are nr)t of crimmon occurrence. 

 The\ ina\- lie present in acute general glanders, the manifesta- 

 tion in the skin Ijcing of the nature of a dift'use gangrenous der- 

 m;ititi^. Cutaneous nodular lesions may become diffuse as a 

 re-ull of rai)ifl and extensive necrosis. Dift'use lesions occur 

 in l\-niphoi(l tissue. Sjilenic lesions are usually nodular though 

 a few oases ]ia\'e been reported in Avhich there were dift'use 

 lesions of the spleen. r)sseous lesions are usually diffuse and 

 appear as a su]5purative osteitis. 



Xridular lesions are common in animals that liaA'e a marked 

 resistance or in those cases infected whh mildlv virulent bac- 

 teria In chronic glanders tlie lesions are usuallv nodular. 



Tlie appearance of nodular lesions in the nasal, pharvngeal 

 and tracheal mucous membranes as well as in the mucous lin- 

 ing of the facial sinus A-aries according to the age of tlie lesion. 

 In the beginning the lymphoid tissue of the mucosa or submu- 

 cosa becomes swc>llen and the tumefaction is surrounded by a 

 hyperemic zone. As the disease progresses there is necrosis 

 which not onlv involves the lesion but also the surface tissue, 

 thus producing an ulcer. The size depth and contour of the 

 ulcer necessarily depend upon the extent of the necrosis. In 

 some instances the nasal septum and facial bones mav be per- 

 forated. The ulcers Aarv in size from mere points to areas as 

 large as a silver dollar. The large ulcers are usually the result 

 of two or more necrotic centers becoming confluent. The de- 

 nuded surface is usually limited or surrounded by a raised 



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