INFICCTUE GRAN ULOilATA. 



367 



lesions are usually few in number and they may he funned hy 

 two or more nodules becoming- confluent. The central caseous 

 necrotic tissue in the small foci frequently becomes calcified 

 Calcification is usually not evident in the large pulmonary les- 

 ions. The bronchial and mediastinal glands are invariably in- 

 volved and they may be caseous, calcified or indurated. 



Nodular lesions of the skin are found in the superficial por- 

 tion of the dermis or in the subcutaneous tissue. The nodules 

 in the skin rarely become larger than a pea but those of the 

 subcutaneous tissue may become as large as a hen's e;'<:. Idie 

 central portion of the cutaneous and subcutaneous nod'^iiles and 





e- 



•V 



V 



Fig, 302 — ]Mioros<'oi)ir Section thrtiugh a glanderous ulcer. 

 Margin of ulcer-necrotic tissue. 

 Normal nasal mucous membrane. 

 Showing deptii of erosion. 

 Small round cells. 

 Epitiieloid cells. 

 Fibrous tissue. 



the superficial tissue covering them become neci'otic au'l a 

 sticky, tenacious, semi-fluid material is discharged ontii the 

 surface. The related lymphatic vessels are all engorged and 

 the lymph nodes are enlarged and later become indurated. 



The tissue destroyed in the lesions of cutaneous glanders 

 mav be partially regenerated, but are more frequently repii.ircd 

 by the substitution of fibrous tissue thus producing a thickened 

 fibrous skin. 



Small nodular lesions have been noted in the spleen, liver 

 and kidney. The splenic lesions may be caseous or calcified. 

 Hepatic lesions are usually caseous. The portal lymph nodes 

 are usually involved when lesions are present in the !i\-er and 



