SCILLA — SQUILL 83 



extract of henega,- 35 mils of fluidextract of squill, 175 mils of 

 paregoric, ammonia water, water and syrup of tolu to make 1000 

 mils. Dose — twice that of the syrup. 



Physiological Action. Squill acts upon the heart much like 

 digitalis. It is also a reliable diuretic acting by both an increased 

 blood pressure in the kidneys and also by direct stimulation of the 

 renal epithelium. It is a more powerful gastro-intestinal irritant 

 than digitalis, often causing vomiting and purging even after moder- 

 ate doses. On account of this action it was formerly used as an 

 emetic. There is also some constituent eliminated by the bronchial 

 mucous membrane on account of which it is a powerful and com- 

 monly employed expectorant. 



Therapeutics. On account of its irritating properties, squill 

 is not often prescribed alone but combined with digitalis, or calomel 

 and digitalis when the latter drug is administered for heart disease 

 or as a diuretic. It is a good expectorant and is especially indi- 

 cated in chronic bronchitis of dogs, usually combined with other 

 drugs as in either of the above syrups or as Stokes' Pectoral Mixture. 



Chronic bronchitis, dog. 



B Syrupi Scillse 3 yj 



Vini Ipecacuanliae r 3 ss 



Syrupi Tolutani 3 vj 



Mucilaginis Aeacise 3 iy 



Aquse q. s ad. S vj 



M. Ft. Solutio. 



Sig. 1, 2 or 3 teaspoonfuls three times daily. 



Other Members of the Group. The other members of this 

 group are convallaria (or lilies of the valley), adonis vernalis, 

 apocynum and euonymous (Wahoo). 



Convallaria is the dried roots and rhizomes of Convallaria 

 majalis, the common lily of the valley. It contains the active glu- 

 coside convallamarin and a saponin-like glucoside of the digitonin 

 type, convallarin. 



Apocynum (Canadian hemp or dog bane) contains the gluco- 

 sides apocynin and apocynein. It is said to produce a digitalis-like 

 action on the circulatory system and is a diuretic. It has been 

 recommended as a substitute for digitalis but is a gastro-intestinal 

 irritant in large doses and at the same time less reliable than 

 digitalis. 



Adonis Vernalis is not official. It contains a glucoside, adoni- 

 din. 



Euonymous resembles the action of digitalis upon the heart but 

 its other action (purgative) predominates so strongly that it is never 

 prescribed for action upon the circulatory system. 



