112 ANTIPYRETICS 



chonine, cinchonidine ; and its action is based principally upon that 

 of quinine. The action of the other alkaloids is similar to quinine 

 but weaker. Quinine may be obtained in any of the following salts : 



Quininse sulphas, soluble in 720 parts of water, in 86 of alcohol, 

 freely soluble in dilute mineral acids as it here forms the double 

 salts; bisulphate, etc. 



Quininae Bisulphas, soluble in 8.5 parts of water and 18 of alcohol. 



Quininse Bromidum, soluble in 40 parts of water and 0.67 of 

 alcohol. 



Quininse Chloridum, soluble in 18 parts of water and 0.6 of 

 alcohol. 



Quininse Salicylicum, soluble in 77 parts of water and 11 of 

 alcohol. 



Cinchoninse Sulphas, soluble in 58 parts of water and 72 of 

 alcohol. 



Quininae et Urese Hydrochloridum is a double salt, soluble in 

 its own weight of water and suitable for hypodermic use. It is 

 anesthetic and non-irritating, but not stable in solutions. 



Euquinine (Quinine-ethyl-carbonic-ester) is insoluble in water 

 and therefore not bitter. It is also said to be followed by less dis- 

 agreeable effects. Its dose is about twice that of quinine, but it is 

 not used to any extent in veterinary medicine. 



Preparations and Doses. 



Fluidextractum Cinchonce and Bark, Astringents. H. Sijss 



— vj; 10—25. D, 5ss— j; 2—5. 

 Extractum, Cinchonce. H. 3ss — ij ; 2 — 8. D. grs. v — ^xxx ; 



0.3—2. 

 Tinctura Cinchonw 20 per cent. D. 3ss — ij ; 2 — 4. 

 Tinciura Cinchonce Composita (10 per cent, with orange 



peel and serpentaria). Dose, double the tincture. 

 Quinince Sulphas Tonic. H. grs. v — xxx; 0.3 — 2. D. grs. 



j — ij; 0.065 — .130. Antipyretic. H. 3ij — viij ; 8. — 



30.' D. G. grs. iij — xv; 0.2^1. 

 Quinince et Urece Hydrochloridum. Quinine and urea hydro- 

 chloride. D. gr. ij — XV ; .013 — 1. Hypodermically in 



a few drops of water. 



Tinctura Antiperiodica. N. F. Warburg's Tincture. Ac- 

 cording to Bastedo, this is a bitter, aromatic, laxative, sedative and 

 antimalarial " gunshot " prescription. It contains quinine sulphate, 

 aloes, rhubarb, angelica seed, elecampane, saffron, fennel, prepared 

 chalk, gentian, cubebs, myrrh, white agaric, opium, black pepper, 

 ginger, alcohol and water. Each ounce contains 10 grains (0.63) of 

 quinine, 8 grains (0.5) of extract of aloes, and % grain (0.008) of 

 opium. Dose for the dog would be about 1 dram. Warburg's tinc- 

 ture without aloes (sine aloe) is the same with the omission of the 



