SALICYLIC ACID 119 



pungent odor, no pronounced taste and nearly insoluble in water. 

 Uses the same as acetanilid. 



Lactophenin (lactyl-para-phenetidinj differs chemically from 

 phenacetin only in having lactic acid in place of the acetic acid con- 

 stituent. It is an antipyretic and analgesic. 



Migranum is a mixture consisting, according to an analysis made 

 at the chemical laboratory of the American Medical Association, of 

 antipyrine^ caffeine, and citric acid. 



Anilipyrine is made by melting together 376 parts of antipyrine 

 and 135 parts of acetanilid. It is antiseptic and analgesic. 



lodophenin or iodophenacetin results from the precipitation of 

 a solution of phenacetin in hydrochloric acid with potassium iodide : 

 brown powder containing about 50 per cent, of iodine, insoluble in 

 water, soluble in alcohol. Used as a wound dressing and antirheu- 

 matic. 



lodopyrin (iodoantipyrine) antipyrine iodide, colorless crystals, 

 soluble in alcohol, slightly soluble in water. Analgesic and alterative 

 in tuberculosis, neuralgia, etc. 



Apolysin is a substance closely related to phenacetin, a citro- 

 paraphenetidin or monocitryl-paraphenetidin. White powder, of 

 faint odor and acidulous taste, moderately soluble in water, more 

 freely so in alcohol or glycerin. Used as an antipyretic and analgesic. 

 It is claimed to be comparatively nontoxic and noncumulative. 



Thermodin is phenacetin-urethane. It consists of colorless, 

 odorless and tasteless crystals, soluble in 2600 parts of water and is 

 used as antipyretic and analgesic the same as acetanilid. 



Neurodin is the trade name for acetyl-para-oxyphenyl-urethane. 

 It occurs as colorless, odorless crystals, slightly soluble in water. 

 Antineuralgic and antipyretic. 



GROUP OF THE SALICYLATES OR ANTIRHEUMATIC 

 ANTIPYRETICS 



ACIDUM SALICYLICUM — SALICYLIC ACID 



Salicylic acid is chemically ortho-salicylic acid. It is an organic 

 acid which exists naturally in the volatile oils of wintergreen and 

 birch but is generally prepared synthetically from phenol. The 

 synthetic acid has been found contaminated with meta and para 

 salicylic acids and with cresotonic acid, which are said to be depress- 

 ing to the circulation, but the commercial acid of the present time is 

 ■ fairly pure and the reported superiority of the natural prodtict is not 

 substantiated as shown by Eggleston, Hatcher and others. Further- 

 more, Engelhardt found phenol present in a number of samples of 

 both the artificial and the natural acids. 



Salicylic acid occurs as small, white needle-like crystals, or a light 

 crystalline powder, odorless, with a sweetish, afterward acrid burning 



